Blocking Agents

Silicon-based blocking agents are used for the protection of active protonated species, in particular alcohols, amines, carboxylic acids, and thiols.  Typical applications are the protection of these groups to allow further transformations on the molecule without reaction at the protected group and to allow the analysis of high boiling molecules such as acids by converting them to the more volatile silyl ether.  Developments over the past several years have centered on the ability to alter the steric and/or electronic nature of the silyl blocking agent to fit the needs of the application in terms of the stability and the ease of deprotection required.  For information of the Gelest, Inc. offering of silicon-based blocking agents see the brochure Silicon-Based Blocking Agents.

Applicable Gelest Brochures:
Silicon-Based Blocking Agents

Key products